Wednesday, July 10, 2019

Partial Transection of Femoral Artery-The advantage of a young age

PARTIAL TRANSECTION OF FEMORAL ARTERY-THE ADVANTAGE OF YOUNG AGE


Being young with optimal physiology makes a lot of difference when it comes to healing as the compensatory mechanisms are all in check. Below is a case history of a 34 years male who was referred 48 hours after suffering a stab wound in his left inner thigh.



(Borrowed from anatomy atlas)

History

A 34 years, African male was out with his friends enjoying a drink when a fight erupted, and someone stabbed him on his left inner thigh with a sharp knife. There was immediate gush of blood and profuse bleeding continued. He was rushed to a nearby health facility.

At the facility, a tourniquet was applied, and pressure packing done. Bleeding minimized but all the packs used, were fully soaked. The tourniquet was intermittently placed and removed to inspect on the bleeding and add on more packs.3-5 Liters of I.V Fluids were given.

After 24 hours when the pressure packing was removed to assess the wound, bleeding was still profuse, described as pulsatile, repacking was done. Gauzes were placed deep into the wound, bleeding was contained. A tourniquet was applied during the packing sessions and removed once bleeding was contained. Patient was kept in this facility for another 24 hours and eventually a decision was made to refer the patient. (Thankfully 😊 )


Examination at Referral

Alert. Sick looking
Severely pale
HR 96 beats/min
BP 92/54
Temp-36.6

Pulsation noted on the packing in the inner left thigh. No color change in the limb, no temperature difference. Weak popliteal and dorsalis pulses were felt. *could perceive pain above knee but numbness below knee reported.

 More layers of packing added. Decision was made to keep the packing for further examination and exploration of the injury in theater.  

He did not have any other injuries.

Lab works Pre-Op
FHG-HCT 15, HB 5, PLT-120
UECS-Na-138, K-4.2, Urea-4, Creatinine-83

4 units of blood secured. I unit given before surgery

*No imaging was done.


Intra-op

Exploration and Findings
Upon removal of gauzes, a gush of bright red blood-pulsatile bleeding continued. Tourniquet applied and more packing was done. The femoral vessels were identified at the inguinal region and clamped. Working with a tourniquet time of 90minutes the injury was explored and repaired as follows:

Wound size-5cm long, 2 cm wide, deep into the muscular region. There were sharp margin cuts across muscle striae. No muscle necrosis noted. There was partial transection of the superficial femoral artery, the posterior wall intact. Femoral Vein was also partially transected. No nerve injuries were visualized.


Repair
Clean cuts were made across the Superficial femoral artery. Primary end to end anastomosis was done. No tension on repaired vessel-Approximate length of lost artery 5mm.

The femoral vein. the margins were freshened and end to end anastomosis done. Heparin infusion was used to flush the vein.

Perforating branched at the site of injury were ligated.

The clamp at the femoral artery was released and flow of blood through the repaired artery was established as satisfactory as well as the venous flow back.

Hemostasis was achieved.

The wound was cleaned and left open. *Fascia not closed. Wound dressings applied. Limb splinted.

Blood loss intraop-1L
Intra-op replacement-1L

*Hemodynamic status- relatively stable intra-op.

Post op

2 more liters of fresh whole blood was given. The limb was immobilized and bed rest for 24 hours. Pain was managed with tramadol and intravenous paracetamol. No bleeding post op. Hemodynamic status of patient were satisfactory with blood pressure remaining above 100/60 and heart rate 80-60 beats per minute

Day 1-4 post op. Pain lessened and numbness though present was reducing in amount. Patient started ambulating with a walk aid. Physiotherapy on limb started. 6 hourly assessments of distal limb pulse and color were satisfactory.

Wound care-Secondary wound repair done on day 4 post op under local anesthesia. Doppler ultrasound done showed satisfactory blood flow through the repaired vessels. Patient was discharged home. Walked with a slight limp. Hb at discharge was 10g/dl.


Follow-up
Review in 2 weeks was unremarkable.



(Borrowed from ImageLib 1994 David Proffitt)
Discussion
The deep femoral artery was intact and could explain how the limb was alive 48 hours after the occurrence of the injury with no muscle necrosis. Other arteries that do not arise from femoral artery were also able to supplement the blood supply to this limb: obturator artery, gluteal arteries

Pressure packing established a stable hematoma, this prevented further bleeding, and this helped in maintenance of hemodynamic status. (Whether some blood was able to flow through the partially transected vessel is unknown) Platelet consumption was very high (PLT just before operation were 120) and thankfully patient did not get into DIC. Infection of the wound was also controlled. Intravenous antibiotics had been given from facility of first contact.

Thrombolytic agents were not used post op. Early ambulation and physiotherapy helped prevent thrombus formation. Young male age was a very favorable factor.



Learning point
Recognition of vascular injuries, referral to center that can repair as well as early involvement of a vascular surgeon.



Tuesday, May 7, 2019


CASE STUDY OF TRANSIENT PSEUDO-HYPOALDOSTERONISM SECONDARY TO RIGHT HEMICOLECTOMY

A 38 years’ lady is admitted as a referral due to suspected intestinal obstruction, previously diagnosed with grade III hiatal hernia. Patient is known to have valvular heart disease for 10 years on management with digoxin 0.125mg and carvedilol 3.25mg. 
Had history of abdominal pains with on and off abdominal distention. Significant rumbling abdominal sound present. Bowel habits reported to have changed in last 2 months.  Had not passed stool in 3 days but was passing flatus.  Anorexia.Significant weight loss reported. No history of night sweats.
Examination.
 Middle aged, obvious wasting. Alert
Mild palmar and conjunctival pallor
CVS-Systolic murmur radiating to the apex
P/A-Scaffold, MWR, Overactive bowel sounds with visible peristaltic activity (Patient severely wasted), no organomegally. DRE-Empty rectum
Resp/Pelvic/CNS-Normal finding.
Lab works
FHG- Hb 10.4 MCV-58.9 WBC-2.9 (Differentials all within normal ranges), PLT-251
UECS-NA-139, Cl-110.9 K-4.13, Urea-3.4, Creatinine-64.47
TFTs-TSH-0.97(N), T3-2.18(N), T4-14.7 (N) 
INR-1.22
LFTs-Albumin 35.89, Total Protein 69.39, SGOT-32, ALP-564, Total Bilirubin 14.1 Direct Bilirubin-9.08, SGPT-17, GGT-84
Imaging
Erect abdominal X-ray-multiple air fluid levels on ascending colon. No sigmoid volvulus. Small gut –no air fluid levels

Management
Patient kept nill per oral
NG tube inserted-bilious fluid aspirated
Maintained on digoxin 0.125mg, Carvedilol 3.25mg, I.V Ceftriaxone 1g Bd, I.V Metronidazole 500mg TDS and IVF RL alternating with D5. 

After 48 hours, clinical resolution of intestinal obstruction observed as characterized by history of passing stool and flatus.
Patient started on liquid diet. After 48 hours no history of passing flatus or stool. Still anorexic.
Decision made to take patient to theatre for explorative laparotomy. ECG Review pre-op, features of left ventricular hypertrophy-cleared for surgery
Pre-op UECS
Na-136, CL-112, K-4.74, Urea-4.10, Creatinine-54.02


Intra-op Findings
Mass at cecum found-intraluminal approx 4* 3 cm. Mass resected whole for biopsy. Right hemicolectomy done. Distal ileum, cecum and ascending colon resected.  Reversal of anesthesia uneventful

Post OP Follow-up
Day 1 and 2, patient recovering well, Feeding started, colostomy site satisfactory. Ambulation started.
Day 3
Dizziness reported. Hypotensive with BPs  88/50mmHg HR 100beats/min. Bolus of NS 1 L given over 1 hour and maintained with 3 L of RL alternating with D5. Carvedilol withheld but digoxin continued 
UECS
Na- 122, Cl 104, K-6.75, Urea-7.28, Creatinine 73.53
Heart stabilized with Calcium gluconate, shifting of potassium done with insulin and D50.
Day 4
Na -122, K-4.97, Urea-8.01 Creatinine 37.9
Patient still hypotensive and lethargic despite being on maintenance fluids 3L and tolerating feeds well. No hyperactivity of colostomy site.
 Day 5
 Na-114.9, Cl 101.6, K-7.41, Urea 13.1, Creatinine 88.32
Heart further stabilized with calcium gluconate, Potassium shifted with insulin and D50 and patient nebulized with salbutamol.
Causes of hyperkalemia reviewed, no direct cause of electrolyte imbalance identified from medications given. A diagnosis of Pseudo-hypo-aldosteronism entertained due to the clinical features of adrenal insufficiency


Patient started on Hydrocortisone as below:
ü  100mg IV bolus then
ü  200mg over 24 hours by continuous infusion day 1
ü  100mg over 24 hours for 2 days

Review of UECS on day 2 after initiation of hydrocortisone
Na-127, K-4.97, Creatinine 37.9 Urea 8.3
On day 3: UECS Na-129, K-4.2, Creatinine 57.0 Urea 7.4

From day 4 hydrocortisone was tapered to P.O 50mg 12 hourly for 3 days. Hypotension resolved to a range of 110-126 systolic and 64-88 diastolic. Heart rate 70-100. Carvedilol was re-introduced.
UECs day 4
Na-135, K-4.25, Urea 6.93, Creatinine 96




Patient was discharged 11 days after operation and 5 days after initiation of hydrocortisone.
 Discharge UECS were: Na-141.9, K-3.86, Urea 3.5, Creatinine-63.49
Medications on discharge: Digoxin 0.125mg, Carvedilol 3.25mg, 50mg of hydrocortisone P.O daily for 4 days, Iron and nutritional supplements.
Colostomy was mature and having normal range output.

Review of Patient three weeks after discharge. 
She was in good general state. Had added weight by 3kgs. BP 118/86 mmhg, HR 76 beats/min
UECS: Na-129, K+-4.6, Creatinine-93 and Urea 4.7
FHG-Hb-11.1, Mcv-62.7, PLT-277, WBC-9.0

Patient was also booked for follow-up with an oncologist with the histology results from the biopsy taken.

Saturday, February 16, 2019

  Posterior Urethral Valves

Making diagnosis in a newborn is not an easy business especially when symptoms are non-specific. The normal culprits are neonatal sepsis. But what happens when things are a bit off and you cannot just say it is  "neonatal sepsis"?



(Borrowed from Pinterest)
Bouncing baby boy is born preterm at 35 weeks. No significant event in the antenatal period. Mother's ANC profile was unremarkable: a 32 year old, para 2+ 1 then, with no co-morbidities. No obstetric ultrasound done in the pregnancy period. Events resulting to premature labor not clear. Fetal distress not reported. 

At birth baby scores 6/1, 7/5 and 8/10. BVM resuscitation done.  Baby taken to nursery with a diagnosis of mild birth asphyxia. Placenta found to be normal. No signs of prematurity from examination of neonate, finstrom score of > 38.

In nursery baby does well. No other events to support birth asphyxia. Baby weaned off oxygen after 24 hours, breastfeeding well. On day 3, some abdominal distention noted. Mother reports baby has not been passing stool but has been passing urine, baby had however passed meconium. On examination, abdomen is distended and soft. Bowel sounds are present. Decision made to insert a flatus tube. Some stool is passed but abdominal distention still present. Aspirate from feeding tube contains milk.  Vital parameters remain normal. NEC is ruled out. Thoughts focus on increasing gut motility by giving erythromycin, keeping flatus tube and normal saline enema. No improvement in symptoms. Baby now is irritable.

Blood is taken for Complete Blood Count and urea, electrolytes and creatinine on day 6 of life. CBC is essentially normal but there is serious derangement in UECS, with urea of 32.50, Creatinine of 673, Potassium of 10.9 and sodium of 112.0.  Re-examination of abdomen is done, consistency of abdomen found to be different with hard mass felt in lower abdomen while rest of abdomen essentially soft and bowel sound present. A urethral catheter inserted to check whether it is urine retention. 80 cc of urine drained. Abdominal distention slightly subsides. Ascites!



(Borrowed from link.springer.com)

Efforts focus on establishing the cause of urine outlet obstruction and correcting the AKI. At this point an impression of posterior urethral valves is made. Baby is taken for an ultrasound scan which confirms the posterior urethral valves plus, significant thickening of bladder wall with key hole sign positive, grade 4 hydronephrosis.




Urethral catheter maintained to help in 
passing urine. UECS improve remarkably as below. The abdominal distention resolved. 

Date
Urea
Creatinine
Na
K
27/01/19
32.5
673.0
112.0
10.9
29/01/19
31.70
365.0
134.0
5.9
30/01/19
12.4
209.0
139.0
6.6
3/02/19
11.3
108
141.0
5.5

Baby was referred to the national hospital for primary valve ablation.